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DoD Amyotrophic Lateral Sclerosis Research Funding Opportunities

17 Apr 2018 9:17 AM | Hawk Tran (Administrator)

FY18 ALSRP Program Announcements and General Application Instructions for the following award mechanisms are posted on the Grants.gov website.

As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency (DHA), J9 Research and Development Directorate manages the Defense Health Program (DHP) Research, Development, Test and Evaluation (RDT&E) appropriation. The managing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP).

The mission of the ALSRP is to fund innovative pre-clinical research to develop new treatments for ALS for the benefit of Service members, Veterans, and the general public.

http://cdmrp.army.mil/funding/alsrp

The following mechanisms are planned for release:

Therapeutic Development Award – Preproposal due June 22, 2018

  • Independent investigators at all academic levels
  • Pre-application is required; full application submission is by invitation only
  • Supports post-discovery, preclinical development of therapeutics for ALS
  • Preliminary data, including identify and purity of an identified bioactive compound(s), are required
  • Types of efforts that will be supported include:
    • Confirmation of candidate therapeutics obtained from screening or by other means
    • Validation of early pilot studies in multiple model systems and/or replicating preliminary data with more time points or additional doses
    • Optimization of potency and pharmacology, studies of formulation, stability and production methods based on Good Manufacturing Practices
    • Investigational New Drug (IND)-enabling studies
  • Clinical trials are not allowed
  • Collaboration with industry is encouraged
  • Does not support screening or development of screens or models
  • New! The following option, with additional funding for qualified applications, is being offered:
  • Therapeutic Relevance Option supports development of markers that will improve the drug development process in parallel with the main therapeutic advancement effort.
  • Applicants must submit a Therapeutic Relevance Statement that clearly describes how the marker is quantifiable and has potential to improve the efficacy of the therapy development process.
  • Application to this option is not a requirement for TDA submission
  • A TDA application requesting the higher level of funding that does not meet the specified criteria may be funded at the lower level
  • Standard award maximum funding of $1,000,000 for direct costs
  • Standard award with Option:
    • If applying for the Therapeutic Relevance Option, maximum funding of up to $1,250,000 for direct costs
  • Maximum period of performance is 2 years
  • Indirect costs may be proposed in accordance with the institution’s negotiated rate agreement.

 

Therapeutic Idea Award – Preproposal due June 22, 2018

  • Independent investigators at all academic levels
  • Pre-application is required; full application submission is by invitation only.
  • Supports new ideas aimed at drug or treatment discovery that are still in the early stages of development
  • Preliminary data are not required
  • Types of efforts that will be supported include:

o    Exploitation of pathways known to be relevant to ALS for the purpose of improving treatment and/or advancing a novel treatment modality

o    Development, modification, and use of high-throughput screens and novel model systems to define or assess lead compounds

o    Projects that focus primarily on investigating the pathophysiology of ALS are outside of the scope of this announcement

  • Maximum funding of $500,000 for direct costs
  • Maximum period of performance is 2 years
  • Indirect costs may be proposed in accordance with the institution’s negotiated rate agreement.

A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline. All applications must conform to the final Program Announcements and General Application Instructions available for electronic downloading from the Grants.gov website. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all CDMRP funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.

Applications must be submitted through the federal government’s single-entry portal, Grants.gov. For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org. For more information about the ALSRP or other CDMRP-administered programs, please visit the CDMRP website (http://cdmrp.army.mil).

Point of Contact:

CDMRP Help Desk
301-682-5507
help@eBrap.org


1717 K ST NW Suite 900

Washington, DC 20006

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